MicroRNA-205 signaling regulates mammary stem cell fate and tumorigenesis
نویسندگان
چکیده
منابع مشابه
MicroRNA-205 signaling regulates mammary stem cell fate and tumorigenesis.
Dysregulation of epigenetic controls is associated with tumorigenesis in response to microenvironmental stimuli; however, the regulatory pathways involved in epigenetic dysfunction are largely unclear. We have determined that a critical epigenetic regulator, microRNA-205 (miR-205), is repressed by the ligand jagged1, which is secreted from the tumor stroma to promote a cancer-associated stem ce...
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Crowe DL, Wan R, Baloue K. 2011. Coordinate activation of the NBS1 gene regulates estradiol mediated protection from double strand DNA breaks. Era of Hope Breast Cancer Research Meeting. Orlando, FL Published manuscripts: Wan R, Crowe DL. 2012. Haploinsufficiency of the Nijmegen breakage syndrome 1 gene increases mammary tumor latency and metastasis. Int J Oncol 41:345-352 Wan R, Wu J, Baloue K...
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Hematopoietic stem cells (HSCs) are historically the most thoroughly characterized type of adult stem cell, and the hematopoietic system has served as a principal model structure of stem-cell biology for several decades. However, paradoxically, although HSCs can be defined by function and even purified to near-homogeneity, the intricate molecular machinery and the signaling mechanisms regulatin...
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ژورنال
عنوان ژورنال: Journal of Clinical Investigation
سال: 2014
ISSN: 0021-9738
DOI: 10.1172/jci73351